Metabolic Correction of Primary Hemostasis in the Acute Phase of Traumatic Brain Injury
| Autor: | G. A. Boyarinov, O. D. Solovyova, E. I. Yakovleva, L V. Boyarinova, A. V. Deryugina |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
endothelium Endothelium Traumatic brain injury medicine.medical_treatment mexicor 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Group A 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Platelet Saline Liver sinusoid RC86-88.9 business.industry traumatic brain injury ethylmethylhydroxypyridine Medical emergencies. Critical care. Intensive care. First aid 030208 emergency & critical care medicine medicine.disease Endothelial stem cell Endocrinology medicine.anatomical_structure nervous system platelets Hepatic stellate cell hepatic sinusoidal capillaries business |
| Zdroj: | Obŝaâ Reanimatologiâ, Vol 17, Iss 1, Pp 57-68 (2021) |
| ISSN: | 2411-7110 1813-9779 |
| DOI: | 10.15360/1813-9779-2021-1-57-68 |
| Popis: | The aim of the study was to investigate the effect of ethylmethylhydroxypyridine on the ultrastructural alterations in endothelial cells of liver sinusoidal capillaries (SC) and primary hemostasis in the acute phase of traumatic brain injury (TBI).Materials and methods. Ultrastructural endothelial cell changes were studied in 36 female outbred rats in the acute phase of TBI using electron microscopy, and the platelet count was determined using a blood analyzer. The experimental group (n=18) animals received intraperitoneal injections of ethylmethylhydroxypyridine at the dose of 8.0 mg/kg per day for 12 days, and the control group (n=18) rats were administered with normal saline solution at the same dose.Results. Administration of ethylmethylhydroxypyridine in the early post TBI period reduced microvilli damage in endothelial, hepatic and stellate cells in the Disse space, whereas in the control group a significant decrease of these cells counts was detected. In contrast to the control group, the experimental group animals did not demonstrate thrombocytopenia on the days 1, 3, and 7 after injury. There was a significant increase in the platelet count compared with the baseline values, which was highest on day 12 after injury.Conclusion. Intraperitoneal administration of ethylmethylhydroxypyridine in rats in early post TBI period inhibited the TBI-associated damaging effect of secondary factors on liver sinusoid endothelial cells and platelet consumption. |
| Databáze: | OpenAIRE |
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