MECHANISM OF INACTIVATION OFS-ADENOSYL-L-HOMOCYSTEINE HYDROLASE BY 5′-DEOXY-5′-S-ALLENYLTHIOADENOSINE AND 5′-DEOXY-5′-S-PROPYNYLTHIOADENOSINE

Autor:	G. Guillerm, D. Guillerm, C. Witkowski-Vandenplas
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Adenosine Hydrolases Stereochemistry Chemistry Adenosylhomocysteinase Placenta General Medicine NAD 5'-Deoxy-5'-S-allenylthioadenosine Biochemistry Enzyme Activation Kinetics Enzyme S-adenosyl-L-homocysteine hydrolase Hydrolase Genetics medicine Humans Molecular Medicine Enzyme Inhibitors medicine.drug
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 20:685-688
ISSN:	1532-2335 1525-7770
DOI:	10.1081/ncn-100002351
Popis:	5'-Deoxy-5'-S-allenylthioadenosine 1 and 5'-deoxy-5'-S-propnylthioadenosine 2, derived from adenosine, were prepared. 1 and 2 caused irreversible inactivation of AdoHcy hydrolase. ESI mass spectra analysis of the inactivated enzyme demonstrated that 1 and 2 were type II "mechanism-based" inhibitors.
Databáze:	OpenAIRE
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