Ginsenoside Rb1 and mitochondria: A short review of the literature
| Autor: | Weijie Xie, Yifan Sun, Ping Zhou, Xiaobo Sun, Guibo Sun, Guang Li, Zi-Ru Dai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ginsenosides
Apoptosis Mitochondrion medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound Mitophagy medicine Animals Humans Panax notoginseng Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species biology 030306 microbiology MPTP Cell Biology biology.organism_classification eye diseases Mitochondria Cell biology Oxidative Stress chemistry Mitochondrial fission Energy Metabolism Reactive Oxygen Species Oxidative stress |
| Zdroj: | Molecular and Cellular Probes. 43:1-5 |
| ISSN: | 0890-8508 |
| DOI: | 10.1016/j.mcp.2018.12.001 |
| Popis: | Mitochondria play a central role in various critical cellular processes, including energy synthesis, energy supply and apoptosis. Panax notoginseng, a commonly used traditional Chinese medicine, has various pharmacological effects on the human body. Ginsenosides are representative bioactive components of P. notoginseng. Recently, more attention has focused on ginsenoside Rb1 as an antioxidative and anti-inflammatory agent that can protect the nervous system and the cardiovascular system. Numerous studies have shown that Rb1 exerts these effects by regulating mitochondrial energy metabolism, mitochondrial fission and fusion, apoptosis, oxidative stress and reactive oxygen species release, mitophagy and mitochondrial membrane potential. Thus, the mitochondria are pivotal targets of Rb1. This review summarized the available reports of the effects of ginsenoside Rb1 on the regulation of mitochondria and showed that it has a promising role in treating mitochondrial diseases. |
| Databáze: | OpenAIRE |
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