An analysis of the ingredients in decoctions and extracts of Kampo medicines: Amounts of baicalin and baicalein in Kampo medicines containing Scutellariae Radix
| Autor: | Noriko Shamoto, Yoshihiro Mimaki, Minpei Kuroda, Takashi Shii |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Kampo
Decoction 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Scutellariae radix Humans Medicine Flavonoids biology Traditional medicine Plant Extracts business.industry Daisaikoto biology.organism_classification 030205 complementary & alternative medicine 0104 chemical sciences Baicalein 010404 medicinal & biomolecular chemistry Aglycone chemistry Flavanones Scutellaria baicalensis Medicine Kampo Geriatrics and Gerontology business Baicalin Drugs Chinese Herbal |
| Zdroj: | Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 57:72-80 |
| ISSN: | 0300-9173 |
| Popis: | Aim Kampo medicines containing Scutellariae Radix (the root of Scutellaria baicalensis Georgi; SR) sometimes cause serious adverse effects, including interstitial pneumonia and liver dysfunction. Baicalin (BL) is the major active component of SR and is presumed to be responsible for the adverse effects. We analyzed the amounts of BL in Kampo medicines to better understand how they can be used safely. Methods We determined the amounts of BL in 28 Kampo decoctions containing SR (recommended daily dose: 1.5-4 g/day) and corresponding Kampo extract products by high-performance liquid chromatography. Results The amounts of BL in the Kampo decoctions were 1.7-4.0-fold higher than those of the corresponding Kampo extract products. Inter-product variations in the amounts of BL in Shosaikoto, Otsujito, Daisaikoto, Saibokuto, Orengedokuto, and Saireito Kampo extracts from various companies were also examined. Significant differences in the amounts of BL were observed for Shosaikoto, Otsujito, Daisaikoto, and Saibokuto extract products (up to 2.6, 1.6, 1.5, and 1.3-fold differences, respectively), whereas no significant differences were observed for Orengedokuto and Saireito extract products. Conclusions Because the Kampo decoctions containing SR that we examined contained 1.7-4.0 times as much BL as the corresponding Kampo extract products, medical doctors and pharmacists should be aware that Kampo decoctions containing SR might cause more severe side effects than corresponding Kampo extract products. Furthermore, we recommend that the amounts of BL and its aglycone, baicalein (BA), in Kampo extract products be made known to practitioners and patients. |
| Databáze: | OpenAIRE |
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