Lens Dose-Response Prediction Modeling and Cataract Incidence in Patients With Retinoblastoma After Lens-Sparing or Whole-Eye Radiation Therapy
| Autor: | Eric L. Chang, A. Linn Murphree, Steven Nguyen, Jesse L. Berry, Arthur J. Olch, Vanessa Salinas, Julian Sison, Jonathan W. Kim, Kenneth Wong, Marjorie T. Jones |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research genetic structures medicine.medical_treatment Kaplan-Meier Estimate Eye 030218 nuclear medicine & medical imaging 0302 clinical medicine Medicine Radiation medicine.diagnostic_test Incidence Incidence (epidemiology) Retinoblastoma Radiotherapy Dosage Progression-Free Survival Oncology Eye examination Child Preschool 030220 oncology & carcinogenesis Female medicine.medical_specialty Retinal Neoplasms Enucleation Cataract Article 03 medical and health sciences Cataracts Ophthalmology Lens Crystalline Humans Radiology Nuclear Medicine and imaging Progression-free survival Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model Infant Dose-Response Relationship Radiation Retrospective cohort study medicine.disease eye diseases Radiation therapy Logistic Models Radiotherapy Intensity-Modulated sense organs Tomography X-Ray Computed business Organ Sparing Treatments Follow-Up Studies |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 103:1143-1150 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2018.12.004 |
| Popis: | PURPOSE: We retrospectively assessed the incidence of cataracts in patients with retinoblastoma (Rb) treated with either lens-sparing radiation therapy (LSRT) or whole-eye radiation therapy (WERT). A secondary aim of this study was to model the dose-response risk of cataract. METHODS AND MATERIALS: We reviewed 65 patients with Rb treated with radiation therapy (RT) at Children’s Hospital, Los Angeles from 1997 to 2015. Eyes that were enucleated before RT or lacked follow-up eye examinations were excluded. All patients underwent computed tomography simulation, and mean lens dose data were collected. Follow-up ophthalmologic examinations and intraocular lens implant history were reviewed for cataracts. The primary event-free survival (EFS) outcome was cataract development. Eyes without cataracts were censored on the last date of eye examination or post-RT enucleation, if applicable. Kaplan-Meier estimates were used to compare EFS outcomes, and dose response was projected with Cox regression and logistic regression models. RESULTS: Sixty-one patients (94 eyes) were analyzed with a median follow-up of 51.8 months. For eyes treated with WERT, cataracts developed in 71.7% versus 35.3% for LSRT. Median EFS for WERT and LSRT were 20.8 and 67.9 months, respectively. Compared with WERT, a significant EFS benefit was demonstrated for LSRT (P |
| Databáze: | OpenAIRE |
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