Cytocompatible Anti-microbial Dressings of Syzygium cumini Cellulose Nanocrystals Decorated with Silver Nanoparticles Accelerate Acute and Diabetic Wound Healing

Autor: Pankaj Markand Kulurkar, S Mahesh, Sourabh Soni, Sudesh Kumar Yadav, Avnesh Kumari, Vikram Patial, Rubbel Singla, Yogendra Padwad
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Angiogenesis
Syzygium
lcsh:Medicine
Biocompatible Materials
02 engineering and technology
Pharmacology
Fibroblast growth factor
01 natural sciences
Silver nanoparticle
Nanocomposites
Mice
Anti-Infective Agents
Materials Testing
lcsh:Science
Multidisciplinary
biology
integumentary system
Chemistry
021001 nanoscience & nanotechnology
Antimicrobial
Immunohistochemistry
Diabetic wound healing
Cytokines
Collagen
Inflammation Mediators
0210 nano-technology
medicine.medical_specialty
Silver
Cell Survival
Neovascularization
Physiologic
010402 general chemistry
Article
Diabetes Complications
medicine
Animals
Cellulose
Mechanical Phenomena
Wound Healing
Spectrum Analysis
lcsh:R
biology.organism_classification
Bandages
0104 chemical sciences
Surgery
Cellulose nanocrystals
Disease Models
Animal
Nanoparticles
lcsh:Q
Wound healing
Zdroj: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
ISSN: 2045-2322
Popis: The ever increasing incidences of non-healing skin wounds have paved way for many efforts on the convoluted process of wound healing. Unfortunately, the lack of relevance and success of modern wound dressings in healing of acute and diabetic wounds still remains a matter of huge concern. Here, an in situ three step approach was embraced for the development of nanocomposite (NCs) dressings by impregnating silver nanoparticles (AgNPs) onto a matrix of cellulose nanocrystals (CNCs) isolated from Syzygium cumini leaves using an environmental friendly approach. Topical application of NCs (ointments and strips) on acute and diabetic wounds of mice documented enhanced tissue repair (~99% wound closure) via decrease in inflammation; increase in angiogenesis, collagen deposition, and rate of neo-epithelialization that ultimately led to formation of aesthetically sound skin in lesser time than controls. Due to the synergistic action of CNCs (having high water uptake capacity) and AgNPs (anti-microbial agents), NCs tend to increase the expression of essential growth factors (FGF, PDGF and VEGF) and collagen while decreasing the pro-inflammatory factors (IL-6 and TNF-α) at the same time, thus accelerating healing. The results suggested the potential of these developed anti-microbial, cytocompatible and nanoporous NCs having optimized AgNPs concentration as ideal dressings for effective wound management.
Databáze: OpenAIRE
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