Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years : TBI is what really matters

Autor: Gérard Michel, C Peters, Miguel Angel Diaz, Patrick Lutz, Petr Sedlacek, Roderick Skinner, A. B. Versluys, Dorine Bresters, Peter J. Shaw, Anita Lawitschka, Maura Faraci, A. Jenkins, Brenda Gibson, Amal Al-Seraihy, Arnaud Dalissier, Nina Salooja, Chiara Cugno, Ulrike Pötschger, Kim Vettenranta, Alison D. Leiper, Mikael Sundin, Peter Bader, Tracey A. O'Brien
Přispěvatelé: Brno University of Technology [Brno] (BUT), Institute of education, Queen Mary University of London (QMUL)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Pediatrics
medicine.medical_specialty
Time Factors
Cross-sectional study
[SHS.PSY]Humanities and Social Sciences/Psychology
Graft vs Host Disease
Malignancy
03 medical and health sciences
0302 clinical medicine
Sex Factors
Risk Factors
medicine
Journal Article
Humans
Transplantation
Homologous
Cumulative incidence
Registries
Transplantation
business.industry
Incidence (epidemiology)
Incidence
Hematopoietic Stem Cell Transplantation
Infant
Hematology
Total body irradiation
medicine.disease
[SHS.ECO]Humanities and Social Sciences/Economics and Finance
3. Good health
Graft-versus-host disease
Cross-Sectional Studies
030220 oncology & carcinogenesis
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Child
Preschool
Hematologic Neoplasms
Quality of Life
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
Thyroid function
business
Whole-Body Irradiation
030215 immunology
Follow-Up Studies
Zdroj: Bone Marrow Transplantation
Bone Marrow Transplantation, Nature Publishing Group, 2016, 51 (11), pp.1482-1489. ⟨10.1038/bmt.2016.139⟩
Bone Marrow Transplantation, 51, 1482–1489. Nature Publishing Group
Bone Marrow Transplantation, 51(11), 1482-1489
ISSN: 0268-3369
DOI: 10.1038/bmt.2016.139⟩
Popis: Younger children are considered to be more vulnerable to late effects (LE), which prompted us to study LE in patients after haematopoietic stem cell transplantation (HSCT) for a haematological malignancy before the age of 3. In this multicentre EBMT study, cumulative incidence (CI) and severity of endocrine LE, central nervous system complications and secondary malignancies at 5, 10, 15 and 20 years of follow-up were assessed. Risk factors (RF) like gender, diagnosis, age at and year of HSCT, TBI- or chemo-conditioning and GVHD were analysed. CI of any LE was 0.30, 0.52, 0.66 and 0.72 at 5, 10, 15 and 20 years after HSCT, respectively. In 25% of the patients, LE were severe at a median follow-up of 10.4 years. In multivariate analysis, only TBI was a RF for having any LE and for thyroid dysfunction and growth disturbance. Female gender was a RF for delayed pubertal development. Some more insight could be gained by descriptive analysis regarding the role of TBI and GVHD on the severity of LE. Although only five selected LE have been studied and median follow-up is relatively short, the incidence and severity of these LE are considerable but not different from what has been found in older children and TBI is the main RF.Bone Marrow Transplantation advance online publication, 27 June 2016; doi:10.1038/bmt.2016.139.
Databáze: OpenAIRE
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