| Autor: |
William S. Fletcher, Moseley Hs, William W. Krippaehne, Benjamin S. Leung |
| Rok vydání: |
1974 |
| Předmět: |
|
| Zdroj: |
The American Journal of Surgery. 128:143-151 |
| ISSN: |
0002-9610 |
| DOI: |
10.1016/0002-9610(74)90086-5 |
| Popis: |
The influence of hormones on the growth of malignant neoplasms has been appreciated since 1896 when Beatson [1] first described two women with advanced breast cancer who responded to oophorectomy. In 1952 Huggins and Bergenstal [2] established the role of bilateral adrenalectomy for palliation of disseminated breast cancer in certain patients. Even though endocrine ablation currently offers the best hope for palliation, only 25 per cent of women with metastatic breast cancer benefit from this procedure [3]. It is probably not applied as frequently or appropriately as it might be because of the lack of an accurate test to predict response and the reluctance of surgeons to perform oophorectomy, adrenalectomy, or hypophysectomy unnecessarily in an already ill patient. At the University of Oregon Medical School, adrenalectomy has been performed for the palliation of breast cancer since 1952. Responses to endocrine ablation have increased steadily over the past twenty-one years as criteria have evolved from random selection to the use of various clinical indexes of hormonal susceptibility and most recently to the development of a biochemical assay specific for estrogen binding in the Cytoplasm of the tumor cell. A retrospective analysis of the clin |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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