Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients

Autor:	Ajay K. Nooka, Magdalena Olszewska-Szopa, Vladimir Maisnar, Giuseppe Mele, Jan Walewski, Massimo Gentile, Agnieszka Druzd-Sitek, Jo Caers, Edvan de Queiroz Crusoe, Andrew Yee, Suzanne Lentzsch, Vania Hungria, Tomas Pika, Julio Dávila, David H. Vesole, Dorotea Fantl, Chaim Shustik, Sonja Zweegman, Xavier Leleu, Morie A. Gertz, Michel Delforge, Aleksander B. Skotnicki, Alessandro Gozzetti, Jorge J. Castillo, Artur Jurczyszyn, Leo Rasche
Přispěvatelé:	Hematology, CCA - Clinical Therapy Development
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Adult Male skin Cancer Research medicine.medical_specialty Poor prognosis Pathology Skin Neoplasms diagnosis Translocation Disease LIGHT CHAIN DISEASE Kaplan-Meier Estimate Translocation Genetic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Genetic 80 and over Medicine Humans Cutaneous myeloma treatment Aged Aged 80 and over Biomarkers Combined Modality Therapy Female Middle Aged Multiple Myeloma Neoplasm Invasiveness Neoplasm Staging Treatment Outcome Hematology Oncology Multiple myeloma integumentary system business.industry Retrospective cohort study medicine.disease Dermatology Cutaneous Involvement Median time 030220 oncology & carcinogenesis Immunohistochemistry business
Zdroj:	Leukemia and Lymphoma, 57(9), 2071-2076. Informa Healthcare Jurczyszyn, A, Olszewska-Szopa, M, Hungria, V, Crusoe, E, Pika, T, Delforge, M, Leleu, X, Rasche, L, Nooka, A K, Druzd-Sitek, A, Walewski, J, Davila, J, Caers, J, Maisnar, V, Gertz, M, Gentile, M, Fantl, D, Mele, G, Vesole, D H, Yee, A J, Shustik, C, Lentzsch, S, Zweegman, S, Gozzetti, A, Skotnicki, A B & Castillo, J J 2016, ' Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients ', Leukemia and Lymphoma, vol. 57, no. 9, pp. 2071-2076 . https://doi.org/10.3109/10428194.2015.1128542
ISSN:	1042-8194
Popis:	Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b17cc3d434dfaee3dbc5f59daec9e6 https://doi.org/10.3109/10428194.2015.1128542 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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