In vitro immunomonitoring of insect venom-allergic patients on immunotherapy

Autor:	Liliana Cifuentes, Ulf Darsow, Markus Ollert, Edzard Spillner, Simon Blank, Mathias Schnedler, Henning Seismann, Davide Pennino, Johannes Ring, Lukas Balzer
Jazyk:	angličtina
Předmět:	Pulmonary and Respiratory Medicine Allergy business.industry medicine.medical_treatment Immunology Specific immunotherapy Venom Immunotherapy medicine.disease In vitro Sting Basophil activation Oral Presentation Immunology and Allergy Medicine Insect venom business
Zdroj:	Clinical and Translational Allergy
ISSN:	2045-7022
DOI:	10.1186/2045-7022-4-s2-o3
Popis:	Objective Sting challenge is the gold standard method to evaluate the therapeutic efficiency of allergen specific immunotherapy (ASIT) in hymenoptera venom allergic patients. Unfortunately, this method is risky, expensive and time consuming. Therefore, the development of an in vitro method is desirable. Recently the basophil activation test (BAT) performed with natural venom has been shown to be a promising method. We aimed to improve the benefit of BAT technology by applying the panel of recombinant allergens Ves v 1, Ves v 2, Ves v 3 and Ves v 5.
Databáze:	OpenAIRE
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