Enucleation for retinoblastoma: the experience of a single center in Jordan

Autor: Maysa Al-Husseini, Ribhi Hazin, Ghadeer Abdeen, Mustafa Mehyar, Saamir Kharma, Mohammad R. Alqudimat, Carlos Rodriguez-Galindo, Iyad Sultan, Ibrahim Qaddoumi, Matthew W. Wilson, Imad Jaradat, Ibrahim Nawaiseh, Arwa Alalami
Rok vydání: 2010
Předmět:
Zdroj: International Ophthalmology. 30:407-414
ISSN: 1573-2630
0165-5701
Popis: Despite multiple advances in the management of retinoblastoma, enucleation remains an essential therapeutic modality. We studied patients who underwent enucleation at the King Hussein Cancer Center in Jordan. We retrospectively reviewed medical records of children with retinoblastoma who were treated at our center from June 2002 to February 2008. Twenty-eight eyes from 27 patients were enucleated. Median age at diagnosis was 1.1 years (range, 0.3-6.3 years). Twenty-six eyes (93%) had advanced disease (RE groups IV and V). Seventeen patients (61%) had unilateral retinoblastoma, and 11 (39%) had bilateral retinoblastoma. The median time from diagnosis to enucleation was 0.45 months (range, 0-45 months; mean, 4.4 months) and was longer for patients with bilateral retinoblastoma (median, 2.2 vs. 0.2 months; P = 0.034). Twenty enucleated eyes (71%) did not show high-risk pathologic features. Seventeen eyes with advanced intraocular disease were enucleated at the time of presentation, whereas chemoreduction was attempted for the other 19 eyes with advanced intraocular disease. Enucleation was then recommended for nine (47%) of those eyes. Enucleation at the time of diagnosis was feasible for most patients with advanced disease. Attempted salvage of eyes with advanced disease is justified, particularly in patients with bilateral disease. We were able to salvage almost half of these eyes. We hope our study provides new insights for counseling patients.
Databáze: OpenAIRE
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