Assessment of dynamic contrast-enhanced magnetic resonance imaging in the differentiation of malignant from benign orbital masses
| Autor: | Xiao-Feng Tao, Xiao-Song Chen, Ying Yuan, Xin-Ping Kuai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Adolescent Statistical difference Contrast Media Sensitivity and Specificity Pattern Recognition Automated Diagnosis Differential Lesion Young Adult Image Interpretation Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Time intensity curve Child Malignant orbital tumor Aged Aged 80 and over Observer Variation medicine.diagnostic_test Receiver operating characteristic business.industry Eye Neoplasms Reproducibility of Results Washout Magnetic resonance imaging General Medicine Middle Aged Image Enhancement Magnetic Resonance Imaging Dynamic contrast medicine.symptom business Nuclear medicine Algorithms |
| Zdroj: | European Journal of Radiology. 82:1506-1511 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2013.03.001 |
| Popis: | Objective Dynamic contrast enhanced MR imaging (DCE-MRI) allows imaging of the physiology of the microcirculation. The purpose of this study was to determine the diagnostic efficacy of time intensity curve (TIC) and DCE parameters for characterization of orbital masses. Methods Fifty-nine patients with untreated orbital lesions underwent DCE-MRI before surgery. For each lesion, peak height (PH), maximum enhancement ratio (ERmax), time of peak enhancement (Tpeak) and maximum rise slope (Slopemax) were plotted and calculated. Receiver operator characteristics (ROC) analysis was conducted to assess the appropriate cut-off value. Results All 26 lesions that demonstrated persistent pattern (type-I) TICs were benign. Most of the masses with the washout pattern (type-III) TIC were malignant (10/14), including lymphoma (n = 6) and melanoma (n = 4). The Slopemax of benign lesions was statistically lower than malignant ones, while the ERmax and Tpeak values of benign lesions were significantly higher. No statistical difference was found in PH (P = 0.121). The AUC for ERmax, Tpeak and Slopemax in differentiating benign orbital lesions from malignant ones were 0.683, 0.837 and 0.738, respectively. In the three DCE parameters, Slopemax cut-off value of 1.10 provided the highest sensitivity of 93.8%; however, the corresponding specificity was low (58.1%). The ERmax cut-off value of 1.37 and Tpeak cut-off value of 35.14 respectively offered the best diagnostic performances. Conclusion DCE-MRI, especially the qualitative TIC pattern and quantitative value of Slopemax, ERmax and Tpeak, could be a complementary investigation in distinguishing malignant orbital tumor from benign ones. |
| Databáze: | OpenAIRE |
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