Diabetic renal failure and serum accumulation of the creatinine oxidative metabolites creatol and methylguanidine
| Autor: | Takahiro Kanatsuna, Motoharu Kondo, Goji Hasegawa, Ko Nakamura, Kazuharu Ienaga, Masahiko Nakai, Yoshio Nakamura, Manabu Sawada, Hiroshi Mori, Koji Nakano |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Metabolite Oxidative phosphorylation Methylguanidine medicine.disease_cause chemistry.chemical_compound Internal medicine medicine Humans Diabetic Nephropathies Autoimmune disease Creatinine business.industry Middle Aged medicine.disease Pathophysiology CTL Oxidative Stress Endocrinology chemistry Kidney Failure Chronic Female business Oxidation-Reduction Oxidative stress |
| Zdroj: | Nephron. 73(4) |
| ISSN: | 1660-8151 |
| Popis: | Diabetic patients (n = 23) with chronic renal failure (CRF) accumulate the creatinine (Cr) oxidative metabolites creatol (CTL) and methylguanidine (MG; a uremic toxin) in their sera. Analysis of serum CTL, a key intermediate in mammalian Cr catabolism into MG, is shown to offer some useful diagnostic information on CRF, especially in the determination of an initial stage of pathological renal failure. The sera of all diabetic (n = 23) and nondiabetic (n = 20) patients with CRF (s-Cr1.25 mg/dl) contained s-CTL (2 micrograms/dl), whereas those from normal subjects (n = 18) and diabetic patients (n = 18) without CRF contained no detectable s-CTL. A similar accumulation of s-MG was observed, but only when s-Cr was higher than 2.0 mg/dl. Although each s-CTL (Y: microgram/dl, Y': mol/l) and s-MG level (Z: microgram/dl, Z': mol/l) is highly correlated with s-Cr (X: mg/dl, X': mol/l) in a normal equation, Y or Z = AX + B, an alternative correlation in a second-order equation, Y or Z = alpha X2 + beta X, could also fit well. Since the quadratic equation can be convertible to Y/X or Z/X = alpha X + beta [Y'/X' or Z'/X' = alpha' X+ beta'] and active oxygen species, especially hydroxyl radicals, convert Cr into CTL, Y/X, Y'/X', Z/X and Z'/X' values which might be a kind of indices for oxygen stress (oxidative stress) increased in proportion to the increased severity of CRF in such patients. Although its meaning and interpretation are still debatable, diabetic CRF patients had a significantly higher alpha' value (2.2) than that (0.89) of nondiabetic CRF patients. All serum values for Cr, CTL and MG were measured with HPLC. |
| Databáze: | OpenAIRE |
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