Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2
| Autor: | Jiashu Hu, Lin Fang, Yijun Deng, Tianqi Wu, Changle Ji, Hongming Song, Dan Xie, Kaiyao Hua |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Article Subject Breast Neoplasms Biology General Biochemistry Genetics and Molecular Biology Metastasis Breast cancer Cell Movement microRNA medicine Humans RNA Neoplasm skin and connective tissue diseases Protein kinase B Aged Cell Proliferation General Immunology and Microbiology Cell growth Akt/PKB signaling pathway Cancer General Medicine Middle Aged medicine.disease Neoplasm Proteins MicroRNAs Apoptosis MCF-7 Cells Cancer research Medicine Female Apoptosis Regulatory Proteins Research Article |
| Zdroj: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2020/7907269 |
| Popis: | Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified. In this study, we found that the expression of miR-30b-5p was upregulated in breast cancer tissues and breast cancer cell lines, compared to paracancer tissues and normal breast cell lines. Moreover, induced overexpression of miR-30b-5p promoted the MDA-MB-231 and HCC 1937 cell growth, migration, and invasion and reduced the cellular apoptosis. Further studies confirmed that miR-30b-5p could directly target ASPP2 and then activate the AKT signaling pathway. Our results suggested that miR-30b-5p could act as a tumor promoter in TNBC. The newly identified miR-30b-5p/ASPP2/AKT axis represents a novel therapeutic strategy for treating TNBC. |
| Databáze: | OpenAIRE |
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