Inflammasomes as therapeutic targets in human diseases
Autor: | Xiangbin Pan, Yao-Hua Song, Yu Zhang, Yangxin Li, Xi-Yong Yu, Zhenya Shen, Bin Liu, Hui Huang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research Inflammasomes QH301-705.5 Interleukin-1beta Inflammation Disease Review Article 03 medical and health sciences 0302 clinical medicine Metabolic Diseases Neoplasms Genetics medicine Pyroptosis Humans Biology (General) Innate immune system Effector business.industry Interleukin-18 Inflammasome Neurodegenerative Diseases Cell biology 030104 developmental biology Cardiovascular Diseases Preclinical research 030220 oncology & carcinogenesis Medicine medicine.symptom business medicine.drug |
Zdroj: | Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-14 (2021) Signal Transduction and Targeted Therapy |
ISSN: | 2059-3635 |
Popis: | Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals. Inflammasome multiprotein complexes are composed of three parts: a sensor protein, an adaptor, and pro-caspase-1. Activation of the inflammasome leads to the activation of caspase-1, which cleaves pro-inflammatory cytokines such as IL-1β and IL-18, leading to pyroptosis. Effectors of the inflammasome not only provide protection against infectious pathogens, but also mediate control over sterile insults. Aberrant inflammasome signaling has been implicated in the development of cardiovascular and metabolic diseases, cancer, and neurodegenerative disorders. Here, we review the role of the inflammasome as a double-edged sword in various diseases, and the outcomes can be either good or bad depending on the disease, as well as the genetic background. We highlight inflammasome memory and the two-shot activation process. We also propose the M- and N-type inflammation model, and discuss how the inflammasome pathway may be targeted for the development of novel therapy. |
Databáze: | OpenAIRE |
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