Development of POEMS syndrome after an initial manifestation of solitary plasmacytoma
| Autor: | Yasumichi Toki, Satoshi Ito, Motohiro Shindo, Ichiki K, Naoka Okamura, Takaaki Hosoki, Yutaka Kohgo, Shinji Watanabe, Katsuya Ikuta, Kazuya Sato, Mayumi Hatayama, Junki Inamura, Yoshihiro Torimoto, Masayo Yamamoto |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Pathology Transplantation Autologous Organomegaly Thoracic Vertebrae Hemangioma Bone Marrow medicine Humans POEMS syndrome Peripheral Blood Stem Cell Transplantation business.industry Hematology medicine.disease ADP-ribosyl Cyclase 1 Transplantation Radiography medicine.anatomical_structure Treatment Outcome POEMS Syndrome Plasmacytoma Histopathology Bone marrow Epidural Neoplasms medicine.symptom business Polyneuropathy Osteosclerosis |
| Zdroj: | International journal of hematology. 93(6) |
| ISSN: | 1865-3774 |
| Popis: | A 44-year-old male was admitted for numbness in the left arm. CT showed a tumor impacting on the spinal cord with an adjacent thoracic vertebral osteosclerotic lesion. The histopathology of the tumor showed diffuse proliferation of atypical plasma cells with expressed vascular endothelial growth factor (VEGF), which is a known etiological factor in POEMS syndrome. Though serum VEGF (sVEGF) level was elevated, a diagnosis of solitary plasmacytoma with an osteosclerotic lesion was made as the patient presented no polyneuropathy, organomegaly, endocrinopathy, or skin changes. The patient experienced muscle weakness of the lower limbs and skin pigmentation/hemangioma one year after irradiation of the osteosclerotic lesion. Laboratory tests revealed hypothyroidism, hyperglycemia, serum monoclonal gammopathy, further elevation of sVEGF, and increased atypical bone marrow plasma cells. CT imaging showed splenomegaly, and a nerve conduction test revealed demyelinating motor peripheral neuropathy. The patient was therefore diagnosed with POEMS syndrome. Plasmacytoma is very rare as an initial manifestation of POEMS syndrome. Patients presenting with plasmacytoma with an osteosclerotic lesion should be carefully observed and evaluated for the expression of sVEGF and development of POEMS syndrome, as most bone plasmacytomas in POEMS syndrome patients are reported to be osteosclerotic. This is to our knowledge the first case of osteosclerotic plasmacytoma that progressed to POEMS syndrome, with an increase of sVEGF. |
| Databáze: | OpenAIRE |
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