Adjustments of muscle capillarity but not mitochondrial protein with skiing in the elderly
| Autor: | Marco Narici, Flemming Dela, Josef Niebauer, Erich Müller, David Niederseer, Peter Scheiber, Martin Flück, Myriam Amami, S van Ginkel |
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| Přispěvatelé: | University of Zurich, Flück, M, Kinesiology, Research Institute MOVE |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Muscle Fibers Skeletal mitochondrial protein Respiratory chain adaptation Hematocrit Muscle hypertrophy capillary Quadriceps Muscle angiogenesis Electron Transport Complex III skiing Heart Rate genetic polymorphism Orthopedics and Sports Medicine genetics Glucose Transporter Type 4 biology medicine.diagnostic_test Electron Transport Complex II VO2 max F(6) ATPase Skeletal Mitochondrial Proton-Translocating ATPases musculoskeletal system coupling factor Adaptation Physiological succinate dehydrogenase (ubiquinone) oxygen consumption Quadriceps femoris muscle Mitochondria aged female Oxidative Phosphorylation Coupling Factors SLC2A4 protein 10046 Balgrist University Hospital Swiss Spinal Cord Injury Center ubiquinol cytochrome c reductase medicine.medical_specialty Vastus lateralis muscle Physiological dipeptidyl carboxypeptidase Neovascularization Physiologic Physical Therapy Sports Therapy and Rehabilitation 610 Medicine & health Peptidyl-Dipeptidase A Muscle Fibers Mitochondrial Proteins 2732 Orthopedics and Sports Medicine SDG 3 - Good Health and Well-being vascularization Genetic Internal medicine Heart rate parasitic diseases glucose transporter 4 medicine reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) Humans skeletal muscle cell human SDHA protein Polymorphism 3612 Physical Therapy Sports Therapy and Rehabilitation Physiologic Exercise Neovascularization ACE NDUFA9 protein Polymorphism Genetic Electron Transport Complex I business.industry NDUFA9 protein human proton transporting adenosine triphosphate synthase SDHA protein human SLC2A4 protein human ubiquinol cytochrome c reductase adaptation anatomy and histology cytology heart rate hematocrit male metabolism physiology quadriceps femoris muscle vascularization Adaptation Physiological Aged Capillaries Female Oxygen Consumption Skiing Glucose Oxygen uptake Polymorphisms Endocrinology biology.protein Physical therapy business human activities GLUT4 |
| Zdroj: | Scandinavian Journal of Medicine and Science in Sports, 25(4), e360-7. Blackwell Munksgaard van Ginkel, S L, Amami, M, Dela, F, Niederseer, D, Narici, M V, Niebauer, J, Scheiber, P, Müller, E & Flück, M 2015, ' Adjustments of muscle capillarity but not mitochondrial protein with skiing in the elderly ', Scandinavian Journal of Medicine and Science in Sports, vol. 25, no. 4, pp. e360-7 . https://doi.org/10.1111/sms.12324 |
| ISSN: | 0905-7188 |
| DOI: | 10.1111/sms.12324 |
| Popis: | Downhill skiing in the elderly increases maximal oxygen uptake (VO2max) and carbohydrate handling, and produces muscle hypertrophy. We hypothesized that adjustments of the cellular components of aerobic glucose combustion in knee extensor muscle, and cardiovascular adjustments, would increase in proportion to VO2max. Nineteen healthy elderly subjects (age 67.5±2.9 years) who completed 28.5 days of guided downhill skiing over 3 months were assessed for anthropometric variables, cardiovascular parameters (heart rate, hematocrit), VO2max, and compared with controls (n=20). Biopsies of vastus lateralis muscle were analyzed for capillary density and expression of respiratory chain markers (NDUFA9, SDHA, UQCRC1, ATP5A1) and the glucose transporter GLUT4. Statistical significance was assessed with a repeated analysis of variance and Fisher's post-hoc test at a P value of 5%. VO2max increased selectively with ski training (+7±2%). Capillary density (+11±5%) and capillary-to-fiber ratio (12±5%), but not the concentration of metabolic proteins, in vastus lateralis were increased after skiing. Cardiovascular parameters did not change. Fold changes in VO2max and capillary-to-fiber ratio were correlated and were under genetic control by polymorphisms of the regulator of vascular tone, angiotensin converting enzyme. The observations indicate that increased VO2max after recreational downhill ski training is associated with improved capillarity in a mainly recruited muscle group. |
| Databáze: | OpenAIRE |
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