Gonadal steroids regulate oxytocin receptors but not vasopressin receptors in the brain of male and female rats. An autoradiographical study
| Autor: | E. Tribollet, Michel Dubois-Dauphin, Jean Jacques Dreifuss, Sylvie Audigier |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Receptors Vasopressin Vasopressin medicine.medical_specialty Oxytocin receptor binding Neurohypophysial hormone Biology Oxytocin Internal medicine medicine Animals Testosterone Molecular Biology Vasopressin receptor Receptors Angiotensin Estradiol General Neuroscience Brain Rats Inbred Strains Oxytocin receptor Rats Arginine Vasopressin Endocrinology Receptors Oxytocin Islands of Calleja Autoradiography Female Neurology (clinical) hormones hormone substitutes and hormone antagonists Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 511:129-140 |
| ISSN: | 0006-8993 |
| Popis: | The distribution and the amount of [3H]oxytocin binding were studied in the brain of adult rats of either sex, as well as in male and female castrates, some of which received injections of estradiol or testosterone. Intact males were treated with an aromatase inhibitor. Castration and inhibition of aromatase activity reduced, whereas estradiol and testosterone increased oxytocin binding, particularly in regions of the brain assumed to be involved in reproductive functions, such as the ventrolateral part of the hypothalamic ventromedial nucleus and the islands of Calleja and neighbouring cell groups. Binding of oxytocin to the uterus was also estrogen-dependent. In the same animals, we also studied the distribution of [3H]vasopressin binding sites present in the brain. It was similar in males and females, and was not affected by experimentally manipulating gonadal hormone levels. In immunocytochemical studies we noticed, as others had previously, that the vasopressin content of certain areas of the rat brain was affected by castration, whereas the oxytocin innervation was not. These results are discussed in relation to the possible functions of oxytocin in the brain and of the lack of correspondence between the immunocytochemical and the autoradiographic data. |
| Databáze: | OpenAIRE |
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