Increased systemic oxygen consumption offsets improved oxygen delivery during dobutamine infusion in newborn lambs
| Autor: | T Sano, J J Smolich, D J Penny |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Cardiac output Drug Evaluation Preclinical Adrenergic Critical Care and Intensive Care Medicine Body Temperature Oxygen Consumption Adrenergic beta-2 Receptor Antagonists Internal medicine Dobutamine Receptors Adrenergic alpha-1 medicine Animals Prospective Studies Cardiac Output Infusions Intravenous Sheep Dose-Response Relationship Drug business.industry Antagonist Age Factors Adrenergic beta-1 Receptor Antagonists Blockade Dose–response relationship Endocrinology Animals Newborn Models Animal Shivering Adrenergic alpha-1 Receptor Antagonists Arterial blood Receptors Adrenergic beta-2 medicine.symptom Blood Gas Analysis Drug Monitoring Receptors Adrenergic beta-1 business medicine.drug |
| Zdroj: | Intensive care medicine. 27(9) |
| ISSN: | 0342-4642 |
| Popis: | Objective: To determine: 1) if dobutamine elicited a thermogenic response during postnatal development; and 2) if this response impacted on the balance between systemic O2 delivery (DO2) and O2 consumption (VO2), and involved one or a combination of adrenoceptor subtypes. Design: Prospective non-randomized unblinded study. Setting: University research laboratory. Subjects: Thirty-five Border-Leicester cross lambs used in a main study performed at 1–2 days (n=7), 7–10 days (n=7), and 6–8 weeks (n=8), and in a adrenoceptor blockade substudy performed at 1–2 days (n=13). Interventions: Lambs were instrumented under anaesthesia and dobutamine was infused at incremental rates of 1–40 µg/kg per minute. In separate subgroups of 1–2 day-old lambs, dobutamine was infused after selective or combined α1, β1, and β2-adrenoceptor blockade. Measurements: Cardiac output, aortic and pulmonary arterial blood gases, and body temperature were measured. DO2 and VO2 were calculated. Main results: Dobutamine increased DO2 similarly at all three ages. Dobutamine also increased VO2 in the absence of muscle shivering, but the average rise in 1–2 day-old lambs was sevenfold to 12-fold greater (P |
| Databáze: | OpenAIRE |
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