Supplementary Figures 1-7, Table 1 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

Autor: Roman K. Thomas, Ralf Küppers, William Pao, Lukas C. Heukamp, Christine M. Lovly, Lydia Meder, Mirjam Koker, Martin L. Sos, Martin Peifer, Florian Malchers, Hyatt Balke-Want, Johannes M. Heuckmann
Rok vydání: 2023
Popis: PDF file - 151K, Supplementary Figure 1 Different EML4-ALK variants elicit similar proliferation rates Supplementary Figure 2 ALK phosphorylation levels after inhibitor treatment Supplementary Figure 3 Schematic representation of EML4-ALK variants 1, 2, 3a and 3b Supplementary Figure 4 TAE684 induced ALK protein degradation Supplementary Figure 5 Protein stability of EML4-ALK variants Supplementary Figure 6 HSP90 inhibitor sensitivity of EML4-ALK variants 2 and 3a Supplementary Figure 7 Bortezomib sensitivity of EML4-ALK variants
Databáze: OpenAIRE