| Autor: |
Weintraub, Daniel, Picillo, Marina, Hyunkeun Ryan Cho, Caspell-Garcia, Chelsea, Blauwendraat, Cornelis, Brown, Ethan G., Chahine, Lana M, Coffey, Christopher S, Dobkin, Roseanne D, Foroud, Tatiana, Galasko, Doug, Kieburtz, Karl, Marek, Kenneth, Merchant, Kalpana, Mollenhauer, Brit, Poston, Kathleen L, Simuni, Tanya, Siderowf, Andrew, Singleton, Andrew, Seibyl, John, Tanner, Caroline M |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.5281/zenodo.7130838 |
| Popis: |
We examined the impact does the dopamine system have on long-term cognitive outcomes in Parkinson disease, and found that lower baseline mean striatum dopamine transporter value, four dopamine-related single-nucleotide polymorphisms, and higher dopaminergic medication exposure all were associated with increased risk for long-term cognitive impairment. Thus, alterations in the dopamine system predict development of clinically-relevant, cognitive impairment in Parkinson disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
