Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity
| Autor: | Christoph Neumayer, Irene Cantone, Sara Carmela Credendino |
|---|---|
| Přispěvatelé: | Credendino, S. C., Neumayer, C., Cantone, I. |
| Rok vydání: | 2020 |
| Předmět: |
genetic variant
cancer and autoimmunity Basic science Autoimmunity Biology medicine.disease_cause Genome Epigenesis Genetic 03 medical and health sciences Sex Factors 0302 clinical medicine Neoplasms Genetics medicine sex bias Humans Epigenetics Precision Medicine 030304 developmental biology Genetic association 0303 health sciences business.industry Cancer medicine.disease Sex bias Evolutionary biology Personalized medicine business epigenetic 030217 neurology & neurosurgery chromatin organization Genome-Wide Association Study |
| Zdroj: | Trends in Genetics. 36:650-663 |
| ISSN: | 0168-9525 |
| DOI: | 10.1016/j.tig.2020.06.016 |
| Popis: | High-throughput sequencing and genome-wide association studies have revealed a sex bias in human diseases. The underlying molecular mechanisms remain, however, unknown. Here, we cover recent advances in cancer and autoimmunity focusing on intrinsic genetic and epigenetic differences underlying sex biases in human disease. These studies reveal a central role of genome regulatory mechanisms including genome repair, chromosome folding, and epigenetic regulation in dictating the sex bias. These highlight the importance of considering sex as a variable in both basic science and clinical investigations. Understanding the molecular mechanisms underlying sex bias in human diseases will be instrumental in making a first step forwards into the era of personalized medicine. |
| Databáze: | OpenAIRE |
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