Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours
| Autor: | Sally M Hunter, Aocs, David D.L. Bowtell, Simone M Rowley, Ian G. Campbell, Richard Lupat, Maria A. Doyle, Prue E. Allan, Kylie L. Gorringe, Jason Li, Genevieve V. Dall |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Exome sequencing Pathology medicine.medical_specialty Cystadenofibroma endocrine system diseases DNA Copy Number Variations Microarrays lcsh:Medicine Trisomy Fibroma General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Medicine Humans Exome Cystadenomas Copy number aberrations lcsh:Science (General) lcsh:QH301-705.5 Chromosome 12 Ovarian Neoplasms Ovarian fibroma business.industry lcsh:R Cancer General Medicine medicine.disease female genital diseases and pregnancy complications body regions Serous fluid stomatognathic diseases Research Note 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Female Gene expression business Adenofibroma lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 13, Iss 1, Pp 1-8 (2020) |
| ISSN: | 1756-0500 |
| Popis: | Objective Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of benign serous ovarian tumours are likely primary fibromas due to the neoplastic alterations being restricted to the stromal compartment of these tumours. We further explore this finding by comparing benign serous tumours to pure fibromas. Results Performing copy number aberration (CNA) analysis on the stromal component of 45 benign serous tumours and 8 pure fibromas, we have again shown that trisomy of chromosome 12 is the most common aberration in ovarian fibromas. CNAs were more frequent in the pure fibromas than the benign serous tumours (88% vs 33%), however pure fibromas more frequently harboured more than one CNA event compared with benign serous tumours. As these extra CNA events observed in the pure fibromas were unique to this subset our data indicates a unique tumour evolution. Gene expression analysis on the two cohorts was unable to show gene expression changes that differed based on tumour subtype. Exome analysis did not reveal any recurrently mutated genes. |
| Databáze: | OpenAIRE |
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