Effects of Gender, Body Composition and Birth Size on IGF-I in 7- and 8-Year-Old Children
| Autor: | Louise A. Baur, C. Tao, V. Petrauskas, Jenny W. Lee, D. Bradford, Sarah P. Garnett, RA Fay, Christopher T. Cowell |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Birth weight Body weight Endocrinology Internal medicine Birth Weight Humans Medicine Insulin-Like Growth Factor I Child Sex Characteristics Dual energy business.industry Body Weight Infant Newborn Total body medicine.disease Body Height Birth size Infant Small for Gestational Age Pediatrics Perinatology and Child Health Body Composition Small for gestational age Female Composition (visual arts) business Sex characteristics |
| Zdroj: | Hormone Research in Paediatrics. 52:221-229 |
| ISSN: | 1663-2826 1663-2818 |
| Popis: | We investigated the relationship between IGF-I, gender, height, weight, body composition and birth size in 260 healthy 7- and 8-year-old children (139 females). All children were born term at Nepean Hospital, Western Sydney. Body composition was measured using dual energy X-ray absorptiometry. IGF-I levels were determined by radioimmunoassay. Girls had higher IGF-I levels than boys (20.2 ± 6.5 nmol/l compared to 15.9 ± 6.1 nmol/l, p < 0.001) but there was no correlation between age and IGF-I. IGF-I was positively correlated with height SDS (R2 = 0.12), weight SDS (R2 = 0.19), BMI SDS (R2 = 0.18), total body fat (%) (R2 = 0.14), and fat-free tissue/cm (R2 = 0.03). After adjusting for gender and current weight, IGF-I-levels were inversely related to birth size – children with the lowest birth size and heaviest current weight had the highest IGF-I levels. This correlation between birth weight and IGF-I supports the hypothesis that the IGF-I axis is altered in babies who are small for gestational age. |
| Databáze: | OpenAIRE |
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