The Effect of pH, Temperature and Certain Media Constituents on the Stability and Activity of the Preservative, Bronopol

Autor:	K. E. Moore, R. J. Stretton
Rok vydání:	1981
Předmět:	Preservative Chromatography Preservatives Pharmaceutical Temperature Bronopol Hydrogen-Ion Concentration Applied Microbiology and Biotechnology Microbiology Culture Media chemistry.chemical_compound chemistry Propylene Glycols Pseudomonas aeruginosa Pharmaceutic Aids
Zdroj:	Journal of Applied Bacteriology. 51:483-494
ISSN:	0021-8847
DOI:	10.1111/j.1365-2672.1981.tb01267.x
Popis:	Various workers have obtained seemingly contradictory results for the activity of the preservative, bronopol. The effect of pH, temperature and certain media constituents on the stability and activity of bronopol has been investigated. Bronopol has been found to be more active at higher pH values but also breaks down at a faster rate. If the activity of bronopol is measured by a system that takes a few minutes, then the true effect of pH on activity is assessed. If, however, the method takes several hours, especially in the presence of certain media constituents, then the compound may decompose significantly and the response to the compound thereby be influenced.
Databáze:	OpenAIRE
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