Influence of Ca2+ Oscillatory Influx on Membrane Ca2+-ATPase Activity: a Kinetic Model
| Autor: | D T Zakrjevskaya, A A Mayevsky, B N Goldstein |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Calcium metabolism biology Erythrocyte Membrane Kinetics Analytical chemistry Biological Transport Active chemistry.chemical_element Calcium-Transporting ATPases General Medicine Calcium Models Biological Biochemistry Signal Enzyme assay Enzyme Membrane chemistry Catalytic cycle Biophysics biology.protein Animals Humans |
| Zdroj: | Biochemistry (Moscow). 70:445-448 |
| ISSN: | 1608-3040 0006-2979 |
| DOI: | 10.1007/s10541-005-0135-y |
| Popis: | A kinetic model for the membrane Ca2+-ATPase is considered. The catalytic cycle in the model is extended by enzyme auto-inhibition and by oscillatory calcium influx. It is shown that the conductive enzyme activity can be registered as damped or sustained Ca2+ pulses similar to observed experimentally. It is shown that frequency variations in Ca2+ oscillatory influx induce changes of pulsating enzyme activity. Encoding is observed for the signal frequency into a number of fixed levels of sustained pulses in the enzyme activity. At certain calcium signal frequencies, the calculated Ca2+-ATPase conductivity demonstrates chaotic multi-level pulses, similar to those observed experimentally. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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