Long-term outcomes and risk factors of thyroid dysfunction during pegylated interferon and ribavirin treatment in patients with chronic hepatitis C infection in Taiwan
Autor: | Yu-Kang Chang, Kou-Huang Chen, Kow-Tong Chen, Yuan-Tsung Tseng |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Goiter Epidemiology Endocrinology Diabetes and Metabolism Hepacivirus lcsh:Diseases of the endocrine glands. Clinical endocrinology Gastroenterology Thyroiditis Polyethylene Glycols chemistry.chemical_compound 0302 clinical medicine Pegylated interferon Risk Factors Medicine Cumulative incidence 030212 general & internal medicine Aged 80 and over Incidence Hazard ratio Thyroid dysfunction General Medicine Middle Aged Prognosis Recombinant Proteins Interferon Drug Therapy Combination Female Thyroid function medicine.drug Research Article Adult medicine.medical_specialty Adolescent Taiwan 030209 endocrinology & metabolism Antiviral Agents 03 medical and health sciences Young Adult Internal medicine Ribavirin Humans Hepatitis C infection Risk factor Aged lcsh:RC648-665 business.industry Interferon-alpha Hepatitis C Chronic medicine.disease Thyroid Diseases chemistry Case-Control Studies Morbidity business Follow-Up Studies |
Zdroj: | BMC Endocrine Disorders BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-9 (2019) |
ISSN: | 1472-6823 |
Popis: | Background This study aimed to investigate the occurrence and risk factors of thyroid dysfunction (TD) in patients with chronic hepatitis C (CHC) infection in Taiwan. Methods The data in this study were obtained from the Taiwan National Health Insurance Research (Taiwan NHIR) database between 2001 and 2013. CHC patients treated with pegylated interferon/ribavirin (PEG-IFN/RBV) were enrolled as case patients, and nontreated CHC patients were enrolled as controls and were matched at a control:case ratio of 3:1 by index date, age (± 3 years), and sex. We compared the cumulative incidence of TD between the cohorts at follow-up until 2013. Results During the study period, 3810 cases and 9393 controls were included in the study. Among the study subjects, 173 (4.5%) case patients and 244 (2.6%) controls were diagnosed with TD during the follow-up period. The types of TD were hypothyroidism (42.9%), hyperthyroidism (31.2%), and thyroiditis (25.9%). Compared to controls during the 13-year follow-up, patients treated with PEG-IFN/RBV had a higher incidence rate of TD (P |
Databáze: | OpenAIRE |
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