Long-term outcomes and risk factors of thyroid dysfunction during pegylated interferon and ribavirin treatment in patients with chronic hepatitis C infection in Taiwan

Autor: Yu-Kang Chang, Kou-Huang Chen, Kow-Tong Chen, Yuan-Tsung Tseng
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Goiter
Epidemiology
Endocrinology
Diabetes and Metabolism
Hepacivirus
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Gastroenterology
Thyroiditis
Polyethylene Glycols
chemistry.chemical_compound
0302 clinical medicine
Pegylated interferon
Risk Factors
Medicine
Cumulative incidence
030212 general & internal medicine
Aged
80 and over
Incidence
Hazard ratio
Thyroid dysfunction
General Medicine
Middle Aged
Prognosis
Recombinant Proteins
Interferon
Drug Therapy
Combination
Female
Thyroid function
medicine.drug
Research Article
Adult
medicine.medical_specialty
Adolescent
Taiwan
030209 endocrinology & metabolism
Antiviral Agents
03 medical and health sciences
Young Adult
Internal medicine
Ribavirin
Humans
Hepatitis C infection
Risk factor
Aged
lcsh:RC648-665
business.industry
Interferon-alpha
Hepatitis C
Chronic
medicine.disease
Thyroid Diseases
chemistry
Case-Control Studies
Morbidity
business
Follow-Up Studies
Zdroj: BMC Endocrine Disorders
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-9 (2019)
ISSN: 1472-6823
Popis: Background This study aimed to investigate the occurrence and risk factors of thyroid dysfunction (TD) in patients with chronic hepatitis C (CHC) infection in Taiwan. Methods The data in this study were obtained from the Taiwan National Health Insurance Research (Taiwan NHIR) database between 2001 and 2013. CHC patients treated with pegylated interferon/ribavirin (PEG-IFN/RBV) were enrolled as case patients, and nontreated CHC patients were enrolled as controls and were matched at a control:case ratio of 3:1 by index date, age (± 3 years), and sex. We compared the cumulative incidence of TD between the cohorts at follow-up until 2013. Results During the study period, 3810 cases and 9393 controls were included in the study. Among the study subjects, 173 (4.5%) case patients and 244 (2.6%) controls were diagnosed with TD during the follow-up period. The types of TD were hypothyroidism (42.9%), hyperthyroidism (31.2%), and thyroiditis (25.9%). Compared to controls during the 13-year follow-up, patients treated with PEG-IFN/RBV had a higher incidence rate of TD (P
Databáze: OpenAIRE
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