Decreased bacterial growth on titanium nanoscale topographies created by ion beam assisted evaporation
| Autor: | Congtin Nguyen, Arash Aslani, Negar H. Golshan, Eric Tobin, Thomas J. Webster, Michelle Stolzoff, Jason E. Burns, Katherine S. Ziemer, Nicholas De La Torre |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus Materials science Nanostructure Ion beam Surface Properties Biophysics Pharmaceutical Science chemistry.chemical_element Bioengineering Nanotechnology 02 engineering and technology Surface finish Bacterial growth Bacterial Adhesion Biomaterials 03 medical and health sciences International Journal of Nanomedicine Drug Discovery Surface roughness Humans bacteria Nanoscopic scale Cells Cultured Cell Proliferation Original Research bone ingrowth Titanium Osteoblasts Photoelectron Spectroscopy Organic Chemistry Prostheses and Implants General Medicine 021001 nanoscience & nanotechnology Evaporation (deposition) Nanostructures IBAD 030104 developmental biology chemistry surface roughness Microscopy Electron Scanning 0210 nano-technology |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Michelle Stolzoff,1 Jason E Burns,2 Arash Aslani,2 Eric J Tobin,2 Congtin Nguyen,1 Nicholas De La Torre,3 Negar H Golshan,3 Katherine S Ziemer,3 Thomas J Webster1,3,4 1Department of Bioengineering, Northeastern University, Boston, 2N2 Biomedical, Bedford, MA, 3Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 4Center of Excellence for Advanced Materials Research, University of King Abdulaziz, Jeddah, Saudi Arabia Abstract: Titanium is one of the most widely used materials for orthopedic implants, yet it has exhibited significant complications in the short and long term, largely resulting from poor cell–material interactions. Among these many modes of failure, bacterial infection at the site of implantation has become a greater concern with the rise of antibiotic-resistant bacteria. Nanostructured surfaces have been found to prevent bacterial colonization on many surfaces, including nanotextured titanium. In many cases, specific nanoscale roughness values and resulting surface energies have been considered to be “bactericidal”; here, we explore the use of ion beam evaporation as a novel technique to create nanoscale topographical features that can reduce bacterial density. Specifically, we investigated the relationship between the roughness and titanium nanofeature shapes and sizes, in which smaller, more regularly spaced nanofeatures (specifically 40–50nm tall peaks spaced ~0.25µm apart) were found to have more effect than surfaces with high roughness values alone. Keywords: titanium, nanostructures, bacteria, bone ingrowth, surface roughness, IBAD |
| Databáze: | OpenAIRE |
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