Retinoblastoma gene product and P21 (WAF1, CIP1) protein expression in non Hodgkin's lymphomas: a multivariate survival analysis

Autor:	Christos Kittas, Panayota Christodoulou, Flora N. Kontopidou, Penelope Korkolopoulou, Davaris P, Efstratios Patsouris, Maria K. Angelopoulou, Gerassimos A. Pangalis
Rok vydání:	2001
Předmět:	Adult Cyclin-Dependent Kinase Inhibitor p21 Male Cancer Research Multivariate analysis Adolescent Biology Protein expression Gene product Cyclins Biomarkers Tumor Humans Genes Retinoblastoma Aged Multivariate survival analysis Aged 80 and over Hodgkin s Lymphoma Non-Hodgkin Hematology Cell cycle Middle Aged Immunohistochemistry Survival Analysis Gene Expression Regulation Neoplastic Oncology P21 waf1 cip1 Multivariate Analysis Cancer research Retinoblastoma gene Female
Zdroj:	Leukemialymphoma. 40(5-6)
ISSN:	1042-8194
Popis:	We evaluated immunohistochemically the expression of two negative regulators of the cell cycle, namely retinoblastoma gene product (pRb) and WAF1/Cip1 gene product (p21), in paraffin sections from 93 patients with non-Hodgkin's lymphomas (NHL) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival. Patients were followed until death (n=33) or for an average of 52 months (60-160). Rb labelling index (LI) increased with malignancy grade and proliferative activity but was unrelated to other clinicopathological parameters. In 33% of cases, especially those of the aggressive groups, we observed diminished pRb expression (i.e. low pRb/Ki-67 ratio). p21 expression on the other hand correlated only with histological grade, Rb LI and p53 LI. In multivariate analysis, Rb LI was a negative predictor of disease-free survival but was linked to a higher probability of complete response. However, diminished pRb expression as well as p21 expression were not statistically significant prognostic indicators. Our results suggest that pRb as a cell cycle related molecule may play an important role in determining prognosis and therapeutic response in NHL patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a5930164cfafb36837ed81d19b804 https://pubmed.ncbi.nlm.nih.gov/11426536 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.