Retinoic acids increase expression of GLUT4 in dedifferentiated and hypertrophied cardiac myocytes
| Autor: | Lis Campos, Christophe Albert Montessuit, Irène Papageorgiou, René Lerch |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Transcription Genetic Physiology Cellular differentiation Tretinoin Muscle hypertrophy Rats Sprague-Dawley Physiology (medical) Internal medicine Gene expression medicine Animals Myocyte Myocytes Cardiac Ventricular remodeling Cells Cultured Glucose Transporter Type 4 Ventricular Remodeling biology Glucose transporter Cell Differentiation Cardiomyopathy Hypertrophic medicine.disease Phenotype Rats Endocrinology biology.protein Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists GLUT4 |
| Zdroj: | Basic Research in Cardiology. 101:27-35 |
| ISSN: | 1435-1803 0300-8428 |
| DOI: | 10.1007/s00395-005-0567-y |
| Popis: | Sufficient expression of the insulin-sensitive glucose transporter GLUT4 may be crucial for the survival of cardiac myocytes in situations of stress. Expression of GLUT4 in cardiac myocytes correlates with cell differentiation and is reduced in the hypertrophied and failing myocardium. Adult rat cardiomyocytes (ARC) in primary culture undergo dedifferentiation and reduction of GLUT4 expression. Depending on the culture condition partial redifferentiation and/or hypertrophy follows. All-trans (at) and 9-cis retinoic acids (RA) are morphogenetic agents important for cell differentiation. Both atRA and 9-cisRA restored GLUT4 expression in dedifferentiated ARC, while only 9-cisRA could increase GLUT4 expression in hypertrophic ARC. The effects of RA were associated with improved differentiation of the cardiac myocytes, as assessed from the expression of atrial natriuretic factor and the morphology of the contractile apparatus. In neonatal rat cardiomyocytes, 9-cisRA, but not atRA, stimulated transcription from the glut4 promoter. In conclusion, treatment with RA can restore the down-regulated expression of GLUT4 in cardiomyocytes in association with a partial improvement of the differentiated phenotype. |
| Databáze: | OpenAIRE |
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