Single and multiple dose pharmacokinetics of lansoprazole in elderly subjects
| Autor: | B Delhotal-Landes, B Flouvat, A Cournot, F Dellatolas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Aging Metabolite Lansoprazole Pharmacology Sulfides Multiple dose Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles chemistry.chemical_compound Pharmacokinetics Oral administration Internal medicine Blood plasma medicine Humans Pharmacology (medical) Dosing Sulfones Enzyme Inhibitors Omeprazole Aged Aged 80 and over Dose-Response Relationship Drug chemistry Area Under Curve Female medicine.drug Research Article |
| Popis: | Plasma concentrations of lansoprazole and of its sulphone, sulphide and 5-hydroxylated metabolites were determined after oral administration of a single 30 mg dose and after 7 days of treatment with a daily 30 mg dose in 12 elderly subjects (mean age 83 years). Results after a single dose were compared with those from a historical control group of 18 young subjects (mean age 23 years). Mean values of AUC after single dose were 2668 ng ml(-1) h in the young subjects and 5216 ng ml(-1) h in the elderly (P < 0.05). Mean t 1/2z values in young and elderly subjects were 1.4 h and 2.9 h, respectively (P < 0.001). Plasma concentrations of the metabolites were similar in both groups. However, the hydroxylated metabolite of the sulphone was detected only in elderly subjects. Steady state plasma concentrations of lansoprazole were reached after 3 days of dosing with lansoprazole. The accumulation ratio was 1.31 in the elderly subjects. |
| Databáze: | OpenAIRE |
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