Acquired Hemophilia a may be Associated with Ticagrelor Therapy in a 52-Year-Old Man after a Recent Percutaneous Transluminal Coronary Angioplasty
| Autor: | Tiziana Capello, Roberto Canaparo, Barbara Deorsola, Claudio Marengo, Laura Perazzolo, Loredana Serpe, Paola Pasquino |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Case Report 030204 cardiovascular system & hematology Bioinformatics ticagrelor 03 medical and health sciences 0302 clinical medicine Prednisone Internal medicine medicine 030212 general & internal medicine platelet aggregation inhibitors Acquired hemophilia A Factor VIII Percutaneous transluminal coronary angioplasty Platelet aggregation inhibitors Ticagrelor Medicine (all) lcsh:R5-920 medicine.diagnostic_test business.industry percutaneous transluminal coronary angioplasty acquired hemophilia A Cancer General Medicine medicine.disease Clopidogrel Effusion factor VIII Cardiology Acquired hemophilia Platelet aggregation inhibitor lcsh:Medicine (General) business medicine.drug Partial thromboplastin time |
| Zdroj: | Clinical Medicine Insights. Case Reports Clinical Medicine Insights: Case Reports, Vol 9 (2016) Clinical Medicine Insights: Case Reports, Vol 2016, Iss 9, Pp 79-81 (2016) |
| ISSN: | 1179-5476 |
| DOI: | 10.4137/ccrep.s39788 |
| Popis: | We present a case report of a 52-year-old man who was hospitalized for right leg pain due to a relevant hemorrhagic effusion. He was on dual antiplatelet therapy (DAPT): acetylsalicylic acid and ticagrelor, a reversible P2Y12 receptor antagonist. Signs, symptoms, and laboratory blood tests led to the diagnosis of acquired hemophilia A (AHA). Ticagrelor therapy-associated AHA was hypothesized due to the fact that, before adding this drug, all laboratory and clinical examinations were repeatedly normal. Prednisone and cyclophosphamide treatment was started without DAPT interruption due to the high risk of stent thrombosis. After 10 days, prolonged activated partial thromboplastin time dropped from 107 to 49 seconds, the patient's factor VIII (FVIII) levels gradually normalized over the following few weeks, and FVIII inhibitor titer was negative. Recently, some reports have established a link between the development of AHA and treatment with clopidogrel, an irreversible P2Y12 receptor antagonist. However, to the best of our knowledge, this is the first time that a link between AHA and ticagrelor has been reported. |
| Databáze: | OpenAIRE |
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