Mass spectrometry-based assay for the rapid detection of thiol-containing natural products
| Autor: | Stacy L. Capehart, Erin E. Carlson |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Natural product 010405 organic chemistry Chemistry Metals and Alloys General Chemistry 010402 general chemistry Mass spectrometry 01 natural sciences Rapid detection Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Reagent Materials Chemistry Ceramics and Composites Thiol Linker Biological evaluation Conjugate |
| Zdroj: | Chemical Communications. 52:13229-13232 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c6cc07111b |
| Popis: | Natural products are privileged scaffolds due to their high propensity to possess bioactivity. To expedite discovery of thiol-containing compounds, we devised a selective solid-supported reagent for their immobilization, followed by cleavage of a photocleavable linker to yield stable natural product conjugates for direct detection by mass spectrometry. Importantly, the natural products can also be tracelessly released to yield the native structures for chemical and biological evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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