Evaluation of sham non‐invasive ventilation for randomized, controlled trials in ALS
| Autor: | Ronald D. Chervin, Eva L. Feldman, Kevin J. Weatherwax, Kirsten L. Gruis, Devin L. Brown |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Research design Vital capacity medicine.medical_specialty medicine.medical_treatment Vital Capacity Placebo law.invention Placebos Randomized controlled trial law medicine Humans Non-invasive ventilation Continuous positive airway pressure Respiratory system Amyotrophic lateral sclerosis Aged Continuous Positive Airway Pressure Pulmonary Gas Exchange business.industry Amyotrophic Lateral Sclerosis General Medicine Middle Aged medicine.disease Respiration Artificial Surgery Neurology Research Design Anesthesia Female Neurology (clinical) business |
| Zdroj: | Amyotrophic Lateral Sclerosis. 7:96-99 |
| ISSN: | 1471-180X 1748-2968 |
| Popis: | Non-invasive positive pressure ventilation (NIV) treatment of advanced respiratory insufficiency prolongs survival in ALS. To investigate the critical question of whether earlier initiation of NIV might provide additional benefit, a randomized trial with an appropriate placebo is needed. This study evaluated sub-therapeutic (sham) continuous positive airway pressure as a potential placebo. In a single-blind design, 40 ALS patients with forced vital capacity>50% were randomized to receive 30 seconds (s) of either active NIV, with 8 cm H2O inspiratory and 4 cm H2O expiratory pressure, or sham NIV with |
| Databáze: | OpenAIRE |
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