Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients
Autor: | Maïa Delage, Olivier Join-Lambert, S. Duchatelet, Olivier Lortholary, Nicolas Lemarchand, H. Coignard, Xavier Nassif, Alain Hovnanian, Aude Nassif, Murielle Alemy-Carreau, S. Miskinyte |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male medicine.medical_specialty Dermatology Severity of Illness Index Sampling Studies Young Adult Drug Delivery Systems Refractory Maintenance therapy Severity of illness Acne Vulgaris medicine Combined Modality Therapy Humans Hidradenitis suppurativa Acne Skin Acne fulminans business.industry Microbiota Syndrome medicine.disease Pyoderma Gangrenosum Anti-Bacterial Agents Hidradenitis Suppurativa Treatment Outcome Female business Pyoderma gangrenosum Follow-Up Studies |
Zdroj: | Journal of the American Academy of Dermatology. 73(5 Suppl 1) |
ISSN: | 1097-6787 |
Popis: | Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases. |
Databáze: | OpenAIRE |
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