ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
| Autor: | Ilkka Pörsti, Johanna Tietäväinen, Outi Laine, Satu Mäkelä, Antti Vaheri, Heini Huhtala, Jukka Mustonen |
|---|---|
| Přispěvatelé: | Medicum, Department of Virology, Tampere University, Department of Internal medicine, Clinical Medicine, Health Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
SUSCEPTIBILITY Gastroenterology Puumala virus Severity of Illness Index DISEASE Disease susceptibility Platelet Puumala hantavirus RISK 11832 Microbiology and virology 0303 health sciences Rh-Hr Blood-Group System Acute kidney injury blood pressure ABO blood groups Acute Kidney Injury Middle Aged University hospital QR1-502 PLATELETS 3. Good health Infectious Diseases Hemorrhagic Fever with Renal Syndrome Female Disease Susceptibility medicine.symptom Hypotension Adult medicine.medical_specialty Inflammation 3121 Internal medicine Microbiology Article ABO Blood-Group System 03 medical and health sciences AKI Virology Internal medicine ABO blood group system capillary leakage medicine Humans 030304 developmental biology 030306 microbiology business.industry medicine.disease NEPHROPATHIA-EPIDEMICA 3141 Health care science Blood pressure 3121 General medicine internal medicine and other clinical medicine 3111 Biomedicine rhesus blood groups business Capillary Leak Syndrome |
| Zdroj: | Viruses Volume 13 Issue 11 Viruses, Vol 13, Iss 2271, p 2271 (2021) |
| ISSN: | 1999-4915 |
| Popis: | Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982–2017. Patients’ blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (n = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection. publishedVersion |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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