Neurostimulation Treatment of OSA
| Autor: | Alan R. Schwartz, David W. Eisele, Luiz Ubirajara Sennes, Thomaz Fleury Curado, Vsevolod Y. Polotsky, Arie Oliven |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Hypoglossal Nerve medicine.medical_treatment Stimulation Electric Stimulation Therapy Critical Care and Intensive Care Medicine Food and drug administration 03 medical and health sciences 0302 clinical medicine Afferent medicine Conceptual foundation Humans Neurostimulation Contemporary Reviews in Sleep Medicine Sleep Apnea Obstructive business.industry Patient Selection Clinical trial Treatment Outcome 030228 respiratory system Genioglossus muscle Cardiology and Cardiovascular Medicine business Hypoglossal nerve Neuroscience 030217 neurology & neurosurgery |
| Popis: | Over the past 30 years, hypoglossal nerve stimulation has moved through a development pathway to become a viable treatment modality for patients with OSA. Initial pilot studies in animals and humans laid the conceptual foundation for this approach, leading to the development of fully implantable stimulating systems for therapeutic purposes. These devices were then shown to be both safe and efficacious in feasibility studies. One such closed-loop stimulating device was found to be effective in treating a limited spectrum of apneic patients and is currently approved by the US Food and Drug Administration for this purpose. Another open-loop stimulating system is currently being rigorously tested in a pivotal trial. Collectively, clinical trials of hypoglossal nerve stimulating systems have yielded important insights that can help optimize therapeutic responses to hypoglossal nerve stimulation. These insights include specific patient selection criteria and methods for delivering stimulation to specific portions of the hypoglossal nerve and/or genioglossus muscle. New approaches for activating efferent and afferent motor pathways are currently in early-stage laboratory development and hold some long-term promise as a novel therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|