Fast track SSTI management program based on a rapid molecular test (GeneXpert® MRSA/SA SSTI) and antimicrobial stewardship
| Autor: | Luis Alcalá, María Auxiliadora Semiglia-Chong, Almudena Burillo, Ana Álvarez-Uría, Raffaella Onori, Emilio Bouza |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Microbiological Techniques 0301 basic medicine Antibiotics lcsh:QR1-502 lcsh:Microbiology law.invention Cohort Studies Antimicrobial Stewardship 0302 clinical medicine law Immunology and Allergy Antimicrobial stewardship Prospective Studies 030212 general & internal medicine Skin Aged 80 and over GeneXpert MTB/RIF General Medicine Middle Aged Staphylococcal Infections Clostridium difficile Abscess Diabetic Foot Hospitals Anti-Bacterial Agents Infectious Diseases Gram staining Molecular Diagnostic Techniques Cellulitis Cohort Female Algorithms Methicillin-Resistant Staphylococcus aureus Microbiology (medical) Staphylococcus aureus medicine.medical_specialty medicine.drug_class 030106 microbiology 03 medical and health sciences Internal medicine medicine Humans Aged General Immunology and Microbiology business.industry Soft Tissue Infections medicine.disease Diabetic foot business |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 53, Iss 2, Pp 328-335 (2020) |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2018.07.008 |
| Popis: | Purpose: This study examines the impacts of a skin and soft tissue infection (SSTI) management program involving a rapid diagnostic algorithm (Gram stain plus real-time PCR, GeneXpert® MRSA/SA SSTI) performed directly on clinical samples plus antimicrobial stewardship (AMS) counseling of the responsible physician. Methods: Participants were 155 consecutive adult inpatients with SSTI and good quality clinical samples submitted to the microbiology laboratory from April 2016 to January 2017. Results of the rapid test and AMS recommendations were phoned through to the responsible physician. The comparison group was a historical cohort. Results: Most SSTI were surgical wound infections (41.3% vs 38.1% for the intervention and comparison groups respectively) followed by diabetic foot (14.2% and 18.1%), abscesses (13.5% both) and cellulitis (12.9% both). Isolated microorganisms were mostly Gram-negative bacilli (two-thirds), followed by Staphylococcus aureus (SA). The ratio methicillin-susceptible SA (MSSA) to methicillin-resistant SA (MRSA) was 4:1. Improvements in the intervention cohort were: DOT (22.0 vs. 24.3 days, p = 0.007), treatment duration per SSTI episode (14.1 vs. 15.0 days, p = 0.072), treatment cost (433.1 vs. 533.3 €, p = 0.039), length of stay (18.6 vs 20.7 days, p = 0.031), related mortality (1 vs. 4 patients, p = 0.022) and Clostridium difficile infection (CDI) (4 vs. 8 patients, p = 0.050). In 48 cases (31.4%) in the intervention group, advice was given to improve empiric antibiotic treatment. Conclusion: This type of program could help adjust antibiotic treatment when inappropriate, reducing antibiotic use and costs, length of stay, CDI and related mortality. Keywords: Antimicrobial stewardship, GeneXpert® MRSA/SA SSTI, Microbiological techniques, Rapid diagnosis, Soft tissue infections |
| Databáze: | OpenAIRE |
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