Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus
| Autor: | D.W. Krause, P.L. Perine, J.E. Mcdade, S. Awoke |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidemic typhus relapsing fever Digoxin Adolescent medicine.drug_class Antibiotics Administration Oral Internal medicine medicine Humans Rickettsia prowazekii Louse-Borne Relapsing Fever Doxycycline business.industry Borrelia Complement Fixation Tests Relapsing Fever General Medicine Lice Infestations medicine.disease Immunology Female Ethiopia Headaches medicine.symptom business Typhus Typhus Epidemic Louse-Borne medicine.drug |
| Zdroj: | Lancet (London, England). 2(7883) |
| ISSN: | 0140-6736 |
| Popis: | 26 patients with louse-borne relapsing fever (L.B.R.F.) and 10 others with serologically proven epidemic typhus were treated with a single oral dose of 100 mg. of doxycycline. All patients were cured and no relapses of L.B.R.F. or typhus occurred during the 2-week period of posttreatment observation. Each of the L.B.R.F. patients experienced a Jarisch-Herxheimer reaction following treatment, which was complicated by hypotension and/or cardiac failure in 5 patients. This was successfully treated with intravenous digoxin. The difficulty of diagnosing typhus and differentiating it from enteric fevers may restrict the use of single-dose doxycycline to epidemics or to mass-treatment campaigns directed at eradicating the human reservoirs of these infections. |
| Databáze: | OpenAIRE |
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