Risk factors for seroma evacuation in breast cancer patients treated with intraoperative radiotherapy
| Autor: | Bartłomiej Masojć, Michał Falco, Magdalena Łukowiak, Agnieszka Czekała, Magdalena Rolla, Andrzej Kram, Mirosław Lewocki, Jolanta Pietruszewska, Agnieszka Rubik-Leszczyńska |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Side effect business.industry Axillary Lymph Node Dissection medicine.disease Confidence interval Surgery 03 medical and health sciences 0302 clinical medicine Increased risk Breast cancer Oncology 030220 oncology & carcinogenesis Seroma medicine Radiology Nuclear Medicine and imaging Original Research Article 030212 general & internal medicine business Intraoperative radiotherapy |
| Zdroj: | Reports of Practical Oncology & Radiotherapy. 21:225-231 |
| ISSN: | 1507-1367 |
| DOI: | 10.1016/j.rpor.2016.03.003 |
| Popis: | Background Novel techniques in oncology provide new treatment opportunities but also introduce different patterns of side effects. Intraoperative radiotherapy (IORT) allows a shortened overall treatment time for early breast cancer either combined with whole breast radiotherapy (WBRT), or alone. Although the early side effects of IORT are well known, data on clinically important late side effects, which require medical intervention, are scarce. Aim In this study, we analyze risk factors for seroma evacuation more than 6 months after IORT. Materials and methods We evaluated 120 patients with a mean follow-up of 27.8 months (range: 7–52 months). Fifty-one patients received IORT only and 69 were additionally treated with WBRT. Results Seroma evacuation was performed 6–38 months after IORT. Two (3.9%) events were observed in the IORT group and 14 (20%) in the IORT + WBRT group. Univariate (Kaplan–Meier) analysis showed that addition of WBRT to IORT increased the risk of seroma evacuation [hazard ratio = 5.5, 95% confidence interval: 2.0–14.7, P = 0.011]. In a multivariate analysis (Cox proportional hazards regression), WBRT and axillary lymph node dissection were significant risk factors for seroma evacuation (model P value = 0.0025). Conclusions WBRT applied after IORT is associated with increased risk of seroma evacuation, which might be considered as a late side effect. |
| Databáze: | OpenAIRE |
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