Obstructive sleep apnoea syndrome and endothelial function: potential impact of different treatment strategies—meta-analysis of prospective studies

Autor: Claudio Galletti, Claudio Vicini, Filippo Montevecchi, Giovanni Cammaroto, Francesco Costa, Marco Valgimigli, Giuseppe Andò, Maria Victoria Garcia Ruiz, Francesco Galletti
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Oral appliance
medicine.medical_treatment
610 Medicine & health
NO
03 medical and health sciences
0302 clinical medicine
stomatognathic system
CPAP
Internal medicine
Humans
Medicine
Prospective Studies
Continuous positive airway pressure
030223 otorhinolaryngology
Prospective cohort study
Obstructive sleep apnoea syndrome
Aged
Sleep Apnea
Obstructive
Continuous Positive Airway Pressure
business.industry
CPAP
Endothelial function
Meta-analysis
OSAS
Oral appliance
Surgery
OSAS
Endothelial function
General Medicine
Middle Aged
nervous system diseases
respiratory tract diseases
Meta-analysis
Otorhinolaryngology
030220 oncology & carcinogenesis
OSAS
Endothelial function
CPAP
Oral appliance
Surgery
Meta-analysis
Cardiology
Treatment strategy
Surgery
Female
Endothelium
Vascular
Neurosurgery
business
Zdroj: Cammaroto, Giovanni; Costa, Francesco; Ruiz, Maria Victoria Garcia; Andò, Giuseppe; Vicini, Claudio; Montevecchi, Filippo; Galletti, Claudio; Galletti, Francesco; Valgimigli, Marco (2019). Obstructive sleep apnoea syndrome and endothelial function: potential impact of different treatment strategies-meta-analysis of prospective studies. European archives of oto-rhino-laryngology, 276(8), pp. 2331-2338. Springer 10.1007/s00405-019-05486-6
ISSN: 1434-4726
0937-4477
Popis: PURPOSE Previous studies have shown an association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular events. Whether this association is mediated by an impairment of endothelial function, which is itself a driver of elevated cardiovascular risk, has yet to be clarified, as it is the eventual protective role of several OSAS treatments. The aim of our meta-analysis is to evaluate the effect of various OSAS treatments on endothelial function calculated by means of flow-mediated dilatation (FMD). METHODS We conducted a meta-analysis of prospective studies including patients affected by mild to severe OSAS treated with continuous positive airway pressure (CPAP), surgery, oral appliance and medical treatments. FMD was measured before and after treatment RESULTS: After pooling results from different treatment strategies, OSAS treatment showed a positive impact on endothelial function (Mean Difference [MD] = 2.58; 95% CI 1.95-3.20; p
Databáze: OpenAIRE
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