Obstructive sleep apnoea syndrome and endothelial function: potential impact of different treatment strategies—meta-analysis of prospective studies
Autor: | Claudio Galletti, Claudio Vicini, Filippo Montevecchi, Giovanni Cammaroto, Francesco Costa, Marco Valgimigli, Giuseppe Andò, Maria Victoria Garcia Ruiz, Francesco Galletti |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Oral appliance medicine.medical_treatment 610 Medicine & health NO 03 medical and health sciences 0302 clinical medicine stomatognathic system CPAP Internal medicine Humans Medicine Prospective Studies Continuous positive airway pressure 030223 otorhinolaryngology Prospective cohort study Obstructive sleep apnoea syndrome Aged Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry CPAP Endothelial function Meta-analysis OSAS Oral appliance Surgery OSAS Endothelial function General Medicine Middle Aged nervous system diseases respiratory tract diseases Meta-analysis Otorhinolaryngology 030220 oncology & carcinogenesis OSAS Endothelial function CPAP Oral appliance Surgery Meta-analysis Cardiology Treatment strategy Surgery Female Endothelium Vascular Neurosurgery business |
Zdroj: | Cammaroto, Giovanni; Costa, Francesco; Ruiz, Maria Victoria Garcia; Andò, Giuseppe; Vicini, Claudio; Montevecchi, Filippo; Galletti, Claudio; Galletti, Francesco; Valgimigli, Marco (2019). Obstructive sleep apnoea syndrome and endothelial function: potential impact of different treatment strategies-meta-analysis of prospective studies. European archives of oto-rhino-laryngology, 276(8), pp. 2331-2338. Springer 10.1007/s00405-019-05486-6 |
ISSN: | 1434-4726 0937-4477 |
Popis: | PURPOSE Previous studies have shown an association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular events. Whether this association is mediated by an impairment of endothelial function, which is itself a driver of elevated cardiovascular risk, has yet to be clarified, as it is the eventual protective role of several OSAS treatments. The aim of our meta-analysis is to evaluate the effect of various OSAS treatments on endothelial function calculated by means of flow-mediated dilatation (FMD). METHODS We conducted a meta-analysis of prospective studies including patients affected by mild to severe OSAS treated with continuous positive airway pressure (CPAP), surgery, oral appliance and medical treatments. FMD was measured before and after treatment RESULTS: After pooling results from different treatment strategies, OSAS treatment showed a positive impact on endothelial function (Mean Difference [MD] = 2.58; 95% CI 1.95-3.20; p |
Databáze: | OpenAIRE |
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