Effect of Postmolding Heat Treatment on In Vitro Properties of a Polyanhydride Implant Containing Gentamicin Sulfate

Autor:	D. Stephens, D. Robinson, Youqin Tian, J. Deng, Lukchiu Li
Rok vydání:	2004
Předmět:	Erucic Acids medicine.medical_specialty Hot Temperature Polymers Pharmaceutical Science chemistry.chemical_element Drug Discovery medicine Copolymer Technology Pharmaceutical Dicarboxylic Acids Antibacterial agent Drug Implants Pharmacology Organic Chemistry Aminoglycoside Nitrogen In vitro Anti-Bacterial Agents Surgery Molecular Weight Gentamicin Sulfate Solubility chemistry Drug release Implant Gentamicins Decanoic Acids Biomedical engineering
Zdroj:	Drug Development and Industrial Pharmacy. 30:341-346
ISSN:	1520-5762 0363-9045
Popis:	A polyanhydride implant containing gentamicin sulfate was fabricated using a laboratory-scale injection-molding machine. After injection molding, the implants were subject to heat treatment at 60 degrees C for various time periods with or without nitrogen protection. The impact of this heat treatment on the in vitro properties of the implants including copolymer molecular weights, mechanical properties, and in vitro drug-release profiles was investigated. This heat treatment caused a drastic drop in the molecular weight of the copolymer. Heating without nitrogen protection resulted in the hardening of the implant, but heating in the presence of nitrogen rendered the implant less rigid. It was also found that a faster in vitro drug release profile was shown by implants heated without nitrogen protection and a pronounced slowing down in drug release was exhibited by implants heated with nitrogen protection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358aa8cafc8c56c56c7e228a20f80384 https://doi.org/10.1081/ddc-120030928 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.