Lupus nephritis in the Western Cape, a high prevalence area: an experience over three decades
| Autor: | U Brijlal, W D Bates, M R Moosa |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Biopsy Kidney Glomerulus 030232 urology & nephrology Lupus nephritis Disease Kaplan-Meier Estimate 03 medical and health sciences South Africa 0302 clinical medicine Rheumatology Predictive Value of Tests Internal medicine medicine Prevalence Humans Lupus Erythematosus Systemic skin and connective tissue diseases Retrospective Studies 030203 arthritis & rheumatology Systemic lupus erythematosus medicine.diagnostic_test business.industry medicine.disease Prognosis Lupus Nephritis Renal pathology Immunology Cohort Disease Progression Histopathology Female Renal biopsy business Kidney disease |
| Zdroj: | Lupus. 26(11) |
| ISSN: | 1477-0962 |
| Popis: | Background Systemic lupus erythematosus is a multisystem disease with serious complications, including lupus nephritis. Systemic lupus erythematosus is prevalent in the Western Cape, predominantly affecting women in the prime of their lives. Renal biopsy is an important tool for the management of the lupus patient with kidney disease, guiding treatment and assessing prognosis. Aims The aim of this study was to ascertain if there has been a change in the spectrum of renal pathology, patient characteristics and long-term outcomes in patients with lupus nephritis in our region over three decades. Methods We reviewed 315 records of systemic lupus erythematosus patients with suspected renal disease who underwent renal biopsy in the Renal Unit at Tygerberg Hospital over three decades between January 1983 and December 2012. Results Lupus nephritis consistently affected young women. Class IV lupus nephritis remained the most common pattern throughout the three decades. The overall five-year survival for this cohort was 67% (95% confidence interval (CI), 60–72%). Conclusion Class IV lupus nephritis remained the most frequent class in our cohort of patients with the poorest survival rates compared to other classes. The prognosis of lupus nephritis in our region is considerably worse than that reported elsewhere in the world. |
| Databáze: | OpenAIRE |
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