Nontuberculous mycobacteria in adult patients with cystic fibrosis
| Autor: | Michael R. Knowles, Lloyd J. Edwards, James R. Yankaskas, W E Highsmith, Peter H. Gilligan, J M Kilby |
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| Rok vydání: | 1992 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Tuberculosis Adolescent Cystic Fibrosis Critical Care and Intensive Care Medicine Gastroenterology Cystic fibrosis Internal medicine medicine Humans Clinical significance Lung biology business.industry Tomography X-Ray Respiratory disease Sputum Nontuberculous Mycobacteria Mycobacterium chelonae biology.organism_classification medicine.disease Mycobacterium avium Complex medicine.anatomical_structure Immunology Nontuberculous mycobacteria Female medicine.symptom Cardiology and Cardiovascular Medicine business Mycobacterium |
| Zdroj: | Chest. 102(1) |
| ISSN: | 0012-3692 |
| Popis: | Because patients with cystic fibrosis (CF) may be predisposed to airway infections with unusual microorganisms, we screened the sputum of adult CF patients for mycobacterial organisms. Acid-fast bacilli (AFB) smears and mycobacterial culture were performed on 297 sputum specimens from 87 patients. Cultures for mycobacteria were frequently overgrown with other bacteria; 22.6 percent of cultures were contaminated. Despite this limitation of mycobacterial culture, 17 patients had at least one positive culture for a Mycobacterium other than tuberculosis (MOTT). Eleven patients were positive for Mycobacterium avium-intracellulare (MAI), two for MAI and M chelonei , three for M chelonei , and one for M fortuitum . None was positive for M tuberculosis . Patients with CF with MOTT were similar to patients with CF without MOTT; only a slightly different (older) age distribution was recognized. The clinical significance of MOTT was difficult to determine in any individual patient, but patients with positive AFB smears appeared more likely to suffer pathogenic effects. We conclude that MOTT is frequently recovered from adult CF patients in the southeastern United States. A specific risk factor for colonization and/or pathogenic infection in Ais patient group was not evident. The general prevalence and clinical pathogenesis in CF patients in the United States remains to be determined. (Cheat 1992; 102:70–75) |
| Databáze: | OpenAIRE |
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