Outcomes of Three- Versus Six-Monthly Dispensing of Antiretroviral Treatment (ART) for Stable HIV Patients in Community ART Refill Groups: A Cluster-Randomized Trial in Zimbabwe
| Autor: | Ashraf Grimwood, Nyika Mahachi, Risa M Hoffman, Charles Chasela, Kudakwashe C. Takarinda, Tsitsi Apollo, Tonderai Kasu, Regis C Choto, Nicoletta Ngorima-Mabhena, Taurayi A. Tafuma, Owen Mugurungi, Trish Muzenda, Eula Mothibi, Geoffrey Fatti |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
antiretroviral treatment
Zimbabwe Male medicine.medical_specialty Time Factors HIV Infections multimonth 030312 virology community ART refill groups Community Networks Drug Prescriptions law.invention Medication Adherence 03 medical and health sciences differentiated service delivery Randomized controlled trial Ambulatory care law Internal medicine Antiretroviral treatment Ambulatory Care Medicine Cluster Analysis Humans Pharmacology (medical) Cluster randomised controlled trial Community Health Services Implementation Science 0303 health sciences business.industry Absolute risk reduction HIV Viral Load Infectious Diseases Treatment Outcome Anti-Retroviral Agents Relative risk Hiv patients HIV-1 Female business Viral load |
| Zdroj: | Journal of Acquired Immune Deficiency Syndromes (1999) |
| ISSN: | 1944-7884 1525-4135 |
| Popis: | Introduction: Multimonth dispensing (MMD) of antiretroviral treatment (ART) aims to reduce patient-related barriers to access long-term treatment and improve health system efficiency. However, randomized evidence of its clinical effectiveness is lacking. We compared MMD within community ART refill groups (CARGs) vs. standard-of-care facility-based ART delivery in Zimbabwe. Methods: A three-arm, cluster-randomized, pragmatic noninferiority trial was performed. Thirty health care facilities and associated CARGs were allocated to either ART collected three-monthly at facility (3MF, control); ART delivered three-monthly in CARGs (3MC); or ART delivered six-monthly in CARGs (6MC). Stable adults receiving ART ≥six months with baseline viral load (VL) |
| Databáze: | OpenAIRE |
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