Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis

Autor:	Aileen Rubio, Lois M. Ednie, Cynthia Whitener, Tatiana Bogdanovich, Kathleen G. Julian, Laura M. Koeth, Martin Roos, Harald Labischinski, Klaudia Kosowska-Shick, Peter C. Appelbaum, Leslie J. Parent
Rok vydání:	2007
Předmět:	Staphylococcus aureus Micrococcaceae medicine.drug_class Antibiotics Bacteremia medicine.disease_cause Microbiology Bacterial Proteins Daptomycin Mechanisms of Resistance Cell Wall Drug Resistance Bacterial medicine Humans Endocarditis Pharmacology (medical) Antibacterial agent Pharmacology biology Acetylation Vancomycin Resistance Endocarditis Bacterial biochemical phenomena metabolism and nutrition Staphylococcal Infections bacterial infections and mycoses Aminoacyltransferases biology.organism_classification medicine.disease Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Phenotype Infectious Diseases Muramic Acids Mutation Vancomycin medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy. 51:3445-3448
ISSN:	1098-6596 0066-4804
Popis:	We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O -acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357ca5cb1e2874009346f296aa258fa8 https://doi.org/10.1128/aac.00559-07 Zobrazit plný text záznamu