Protective effects of intraperitoneal administration of nimodipine on ischemia–reperfusion injury in ovaries: Histological and biochemical assessments in a rat model
| Autor: | Mones Moloody–Tapeh, Rahim Mohammadi, Tahereh Behroozi-Lak, Leila Zarei, Negin Farhad |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Rat model Ischemia Ovary 030226 pharmacology & pharmacy Random Allocation 03 medical and health sciences 0302 clinical medicine Laparotomy medicine Animals Ovarian Diseases cardiovascular diseases Rats Wistar Nimodipine business.industry Ovarian torsion General Medicine Calcium Channel Blockers medicine.disease Rats Treatment Outcome medicine.anatomical_structure Reperfusion Injury 030220 oncology & carcinogenesis Anesthesia Pediatrics Perinatology and Child Health Female Surgery Histopathology business Reperfusion injury Biomarkers Injections Intraperitoneal medicine.drug |
| Zdroj: | Journal of Pediatric Surgery. 52:602-608 |
| ISSN: | 0022-3468 |
| Popis: | Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of intraperitoneal administration of nimodipine on ischemia-reperfusion injury in ovaries.Thirty healthy male Wistar rats weighing approximately 250g were randomized into six experimental groups (n=5): Group Sham: The rats underwent only laparotomy. Group I: A 3-h ischemia only. Group I/R: A 3-h ischemia and a 3-h reperfusion. Group I/Nimodipine: A 3-h ischemia only and 1mg/kg intraperitoneal administration of nimodipine 2.5h after induction of ischemia. Group I/R/Nimodipine: A 3-h ischemia, a 3-h reperfusion and 1mg/kg intraperitoneal administration of nimodipine 2.5h after induction of ischemia.Nimodipine treated animals showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (P0.05). The significant higher values of SOD, tGSH, GPO, GSHRd and GST were observed in I/R/Nimodipine animals compared to those of other groups (P0.05). The damage indicators (NOS, MDA, MPO and DNA damage level) were significantly lower in I/R/Nimodipine animal compared to those of other groups (P0.05).Intraperitoneal administration of nimodipine could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect