Gaditanone, a Diterpenoid Based on an Unprecedented Carbon Skeleton Isolated from Euphorbia gaditana
| Autor: | David Zorrilla, Antonio J. Macías-Sánchez, José Manuel Botubol-Ares, M. Eugenia Flores-Giubi, Rosario Hernández-Galán, Felipe Escobar-Montaño, María Jesús Durán-Peña |
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| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
Euphorbia Molecular Structure biology 010405 organic chemistry Stereochemistry Organic Chemistry Carbon skeleton Pharmaceutical Science 010402 general chemistry biology.organism_classification Ring (chemistry) 01 natural sciences Terpenoid Biosynthetic Pathways 0104 chemical sciences Analytical Chemistry Complementary and alternative medicine Spain Drug Discovery Molecular Medicine Diterpenes Nuclear Magnetic Resonance Biomolecular |
| Zdroj: | Journal of Natural Products. 80:2161-2165 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A novel diterpenoid, gaditanone (2), which possesses an unprecedented 5/6/4/6-fused gaditanane tetracyclic ring skeleton, and a new jatrophane (1) were isolated from the aerial parts of Euphorbia gaditana. The chemical structures and absolute configurations were determined by extensive spectroscopic NMR studies and ECD data analysis. A proposed biosynthetic pathway is presented for compound 2. |
| Databáze: | OpenAIRE |
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