Effects of Polyphenols from Grape Seeds on Renal Lithiasis
Autor: | Fernando Tur, Antonia Costa-Bauzá, J. J. Torres, Felix Grases, Rafel A. Fernandez-Cabot, Rafel M. Prieto |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Male
Aging Ethylene Glycol Antioxidant medicine.medical_treatment Pharmacology Lithiasis medicine.disease_cause ratas Kidney Biochemistry enfermedades renales Catechin calcio Magnesium Vitis lcsh:Cytology food and beverages Phosphorus General Medicine extracto de semillas de uva medicine.anatomical_structure Renal papilla Grape seed extract Seeds catequina Kidney Diseases Research Article semillas food.ingredient Article Subject chemistry.chemical_element Calcium Ammonium Chloride litiasis food glicol de etileno magnesio medicine fósforo Animals lcsh:QH573-671 polifenoles Rats Wistar Grape Seed Extract riñón peso corporal Body Weight Kidney metabolism Polyphenols Cell Biology medicine.disease Rats chemistry cloruro de amonio animales Oxidative stress Calcification |
Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2015 (2015) |
ISSN: | 1942-0994 1942-0900 |
Popis: | Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcification depends on preexisting injury and involves reactive oxygen species. Many plant extracts that protect against oxidative stressmanifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Rats were pretreated with polyphenols and grape seed extracts, followed by posterior induction of hyperoxalosis via treatment with ethylene glycol plus NH4Cl. The concentrations of calcium and other elements in kidney were determined, along with histological examination of kidney and 24 h urine analysis. Significant differences were observed in the renal calcium content between the control plus ethylene glycol-treated group and the epicatechin plus ethylene glycol-treated, red grape seed extract plus ethylene glycol-treated, and white grape seed extract plus ethylene glycol-treated groups, with reductions of about 50%. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation, particularly if calculi are induced by lesions caused by cytotoxic compounds with oxidative capacity. This work was supported by the Project Grant, CTQ2010-18271, from the Ministerio de Ciencia e Innovacion (Gobierno de Espana), FEDER funds (European Union), and the Project Grant 9/2011 from the Conselleria d'Educacio, Cultura i Universitat (Govern de les Illes Balears). The authors are additionally grateful to Output Trade S.L. (Vilafranca del Penedes, Spain) for supplying the white grape seed extract. |
Databáze: | OpenAIRE |
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