Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease
| Autor: | D. W. Miller, A. K. Emelyanov, S. N. Pchelina, A. L. Schwarzman, A. F. Yakimovskii, I. G. Shabalina, A. S. Drozdova |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pathology Parkinson's disease Disease Protein Serine-Threonine Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Gastroenterology General Biochemistry Genetics and Molecular Biology Internal medicine medicine Leukocytes Humans In patient Aged Kinase business.industry Parkinson Disease General Medicine Middle Aged medicine.disease LRRK2 Peripheral blood nervous system diseases Mutation Etiology alpha-Synuclein α synuclein Female business |
| Zdroj: | Bulletin of experimental biology and medicine. 150(6) |
| ISSN: | 1573-8221 |
| Popis: | Measurement of α-synuclein level in the peripheral blood was proposed as a diagnostic test for Parkinson’s disease. However, the results of these studies remain contradictory, probably because the examined samples included patients with different etiology of Parkinson’s disease. To verify this assumption we studied the levels of α-synuclein in peripheral blood leukocytes of patients with Parkinson’s disease associated with mutations in the gene of leucine-rich kinase 2 (LRRK2). The mean α-synuclein level was signifi cantly lower in patients with LRRK2-associated Parkinson’s disease (N=8) than in patients with sporadic form of the disease (N=33; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink